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The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy

Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not repaired by 8-oxoG repair systems. Therefore, the accumulation of 8-oxoG plays an essential role in tumorigenesis. To avoid...

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Autores principales: Li, Chunshuang, Xue, Yaoyao, Ba, Xueqing, Wang, Ruoxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735852/
https://www.ncbi.nlm.nih.gov/pubmed/36497058
http://dx.doi.org/10.3390/cells11233798
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author Li, Chunshuang
Xue, Yaoyao
Ba, Xueqing
Wang, Ruoxi
author_facet Li, Chunshuang
Xue, Yaoyao
Ba, Xueqing
Wang, Ruoxi
author_sort Li, Chunshuang
collection PubMed
description Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not repaired by 8-oxoG repair systems. Therefore, the accumulation of 8-oxoG plays an essential role in tumorigenesis. To avoid the accumulation of 8-oxoG in the genome, base excision repair (BER), initiated by 8-oxoguanine DNA glycosylase1 (OGG1), is responsible for the removal of genomic 8-oxoG. It has been proven that 8-oxoG levels are significantly elevated in cancer cells compared with cells of normal tissues, and the induction of DNA damage by some antitumor drugs involves direct or indirect interference with BER, especially through inducing the production and accumulation of reactive oxygen species (ROS), which can lead to tumor cell death. In addition, the absence of the core components of BER can result in embryonic or early post-natal lethality in mice. Therefore, targeting 8-oxoG repair systems with inhibitors is a promising avenue for tumor therapy. In this study, we summarize the impact of 8-oxoG accumulation on tumorigenesis and the current status of cancer therapy approaches exploiting 8-oxoG repair enzyme targeting, as well as possible synergistic lethality strategies involving exogenous ROS-inducing agents.
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spelling pubmed-97358522022-12-11 The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy Li, Chunshuang Xue, Yaoyao Ba, Xueqing Wang, Ruoxi Cells Review Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not repaired by 8-oxoG repair systems. Therefore, the accumulation of 8-oxoG plays an essential role in tumorigenesis. To avoid the accumulation of 8-oxoG in the genome, base excision repair (BER), initiated by 8-oxoguanine DNA glycosylase1 (OGG1), is responsible for the removal of genomic 8-oxoG. It has been proven that 8-oxoG levels are significantly elevated in cancer cells compared with cells of normal tissues, and the induction of DNA damage by some antitumor drugs involves direct or indirect interference with BER, especially through inducing the production and accumulation of reactive oxygen species (ROS), which can lead to tumor cell death. In addition, the absence of the core components of BER can result in embryonic or early post-natal lethality in mice. Therefore, targeting 8-oxoG repair systems with inhibitors is a promising avenue for tumor therapy. In this study, we summarize the impact of 8-oxoG accumulation on tumorigenesis and the current status of cancer therapy approaches exploiting 8-oxoG repair enzyme targeting, as well as possible synergistic lethality strategies involving exogenous ROS-inducing agents. MDPI 2022-11-27 /pmc/articles/PMC9735852/ /pubmed/36497058 http://dx.doi.org/10.3390/cells11233798 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Chunshuang
Xue, Yaoyao
Ba, Xueqing
Wang, Ruoxi
The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy
title The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy
title_full The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy
title_fullStr The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy
title_full_unstemmed The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy
title_short The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy
title_sort role of 8-oxog repair systems in tumorigenesis and cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735852/
https://www.ncbi.nlm.nih.gov/pubmed/36497058
http://dx.doi.org/10.3390/cells11233798
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