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The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy
Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not repaired by 8-oxoG repair systems. Therefore, the accumulation of 8-oxoG plays an essential role in tumorigenesis. To avoid...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735852/ https://www.ncbi.nlm.nih.gov/pubmed/36497058 http://dx.doi.org/10.3390/cells11233798 |
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author | Li, Chunshuang Xue, Yaoyao Ba, Xueqing Wang, Ruoxi |
author_facet | Li, Chunshuang Xue, Yaoyao Ba, Xueqing Wang, Ruoxi |
author_sort | Li, Chunshuang |
collection | PubMed |
description | Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not repaired by 8-oxoG repair systems. Therefore, the accumulation of 8-oxoG plays an essential role in tumorigenesis. To avoid the accumulation of 8-oxoG in the genome, base excision repair (BER), initiated by 8-oxoguanine DNA glycosylase1 (OGG1), is responsible for the removal of genomic 8-oxoG. It has been proven that 8-oxoG levels are significantly elevated in cancer cells compared with cells of normal tissues, and the induction of DNA damage by some antitumor drugs involves direct or indirect interference with BER, especially through inducing the production and accumulation of reactive oxygen species (ROS), which can lead to tumor cell death. In addition, the absence of the core components of BER can result in embryonic or early post-natal lethality in mice. Therefore, targeting 8-oxoG repair systems with inhibitors is a promising avenue for tumor therapy. In this study, we summarize the impact of 8-oxoG accumulation on tumorigenesis and the current status of cancer therapy approaches exploiting 8-oxoG repair enzyme targeting, as well as possible synergistic lethality strategies involving exogenous ROS-inducing agents. |
format | Online Article Text |
id | pubmed-9735852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97358522022-12-11 The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy Li, Chunshuang Xue, Yaoyao Ba, Xueqing Wang, Ruoxi Cells Review Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not repaired by 8-oxoG repair systems. Therefore, the accumulation of 8-oxoG plays an essential role in tumorigenesis. To avoid the accumulation of 8-oxoG in the genome, base excision repair (BER), initiated by 8-oxoguanine DNA glycosylase1 (OGG1), is responsible for the removal of genomic 8-oxoG. It has been proven that 8-oxoG levels are significantly elevated in cancer cells compared with cells of normal tissues, and the induction of DNA damage by some antitumor drugs involves direct or indirect interference with BER, especially through inducing the production and accumulation of reactive oxygen species (ROS), which can lead to tumor cell death. In addition, the absence of the core components of BER can result in embryonic or early post-natal lethality in mice. Therefore, targeting 8-oxoG repair systems with inhibitors is a promising avenue for tumor therapy. In this study, we summarize the impact of 8-oxoG accumulation on tumorigenesis and the current status of cancer therapy approaches exploiting 8-oxoG repair enzyme targeting, as well as possible synergistic lethality strategies involving exogenous ROS-inducing agents. MDPI 2022-11-27 /pmc/articles/PMC9735852/ /pubmed/36497058 http://dx.doi.org/10.3390/cells11233798 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Chunshuang Xue, Yaoyao Ba, Xueqing Wang, Ruoxi The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy |
title | The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy |
title_full | The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy |
title_fullStr | The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy |
title_full_unstemmed | The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy |
title_short | The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy |
title_sort | role of 8-oxog repair systems in tumorigenesis and cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735852/ https://www.ncbi.nlm.nih.gov/pubmed/36497058 http://dx.doi.org/10.3390/cells11233798 |
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