Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF(V600E) Protein

BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAF(V600E) mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hampered by resistance mechanisms. The PROTAC-induced degradation...

Descripción completa

Detalles Bibliográficos
Autores principales: Marini, Elisabetta, Marino, Marco, Gionfriddo, Giulia, Maione, Federica, Pandini, Marta, Oddo, Daniele, Giorgis, Marta, Rolando, Barbara, Blua, Federica, Gastaldi, Simone, Marchiò, Serena, Kovachka, Sandra, Spyrakis, Francesca, Gianquinto, Eleonora, Di Nicolantonio, Federica, Bertinaria, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736157/
https://www.ncbi.nlm.nih.gov/pubmed/36500607
http://dx.doi.org/10.3390/molecules27238513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736157/
https://www.ncbi.nlm.nih.gov/pubmed/36500607
http://dx.doi.org/10.3390/molecules27238513

Ejemplares similares