Development and Validation for Quantification of 7-Nitroso Impurity in Sitagliptin by Ultraperformance Liquid Chromatography with Triple Quadrupole Mass Spectrometry

The purpose of this research study was to develop an analytical method for the quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4] triazolo [4,3-a] pyrazine (7-nitroso impurity), which is a potential genotoxic impurity. Since sitagliptin is an anti-diabetic medication used to...

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Detalles Bibliográficos
Autores principales: Chittireddy, Hari Naga Prasada Reddy, Kumar, J. V. Shanmukha, Bhimireddy, Anuradha, Shaik, Mohammed Rafi, Khan, Merajuddin, Adil, Syed Farooq, Khan, Mujeeb, Aldhuwayhi, Fatimah N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736263/
https://www.ncbi.nlm.nih.gov/pubmed/36500672
http://dx.doi.org/10.3390/molecules27238581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736263/
https://www.ncbi.nlm.nih.gov/pubmed/36500672
http://dx.doi.org/10.3390/molecules27238581

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