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Development and Validation for Quantification of 7-Nitroso Impurity in Sitagliptin by Ultraperformance Liquid Chromatography with Triple Quadrupole Mass Spectrometry
The purpose of this research study was to develop an analytical method for the quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4] triazolo [4,3-a] pyrazine (7-nitroso impurity), which is a potential genotoxic impurity. Since sitagliptin is an anti-diabetic medication used to...
Autores principales: | Chittireddy, Hari Naga Prasada Reddy, Kumar, J. V. Shanmukha, Bhimireddy, Anuradha, Shaik, Mohammed Rafi, Khan, Merajuddin, Adil, Syed Farooq, Khan, Mujeeb, Aldhuwayhi, Fatimah N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736263/ https://www.ncbi.nlm.nih.gov/pubmed/36500672 http://dx.doi.org/10.3390/molecules27238581 |
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