Shifting the pH Optima of (R)-Selective Transaminases by Protein Engineering

Amine transaminases (ATAs) are powerful biocatalysts for the stereoselective synthesis of chiral amines. However, wild-type ATAs usually show pH optima at slightly alkaline values and exhibit low catalytic activity under physiological conditions. For efficient asymmetric synthesis ATAs are commonly...

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Detalles Bibliográficos
Autores principales: Xiang, Chao, Ao, Yu-Fei, Höhne, Matthias, Bornscheuer, Uwe T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736275/
https://www.ncbi.nlm.nih.gov/pubmed/36499674
http://dx.doi.org/10.3390/ijms232315347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736275/
https://www.ncbi.nlm.nih.gov/pubmed/36499674
http://dx.doi.org/10.3390/ijms232315347

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