Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein

Several strands of investigation have established that a reduction in the levels of the cellular prion protein (PrP(C)) is a promising avenue for the treatment of prion diseases. We recently described an indirect approach for reducing PrP(C) levels that targets Na,K-ATPases (NKAs) with cardiac glyco...

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Detalles Bibliográficos
Autores principales: Eid, Shehab, Zerbes, Thomas, Williams, Declan, Wang, Xinzhu, Sackmann, Chris, Meier, Sammy, Dulin, Nickolai O., Nagorny, Pavel, Schmitt-Ulms, Gerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736291/
https://www.ncbi.nlm.nih.gov/pubmed/36499150
http://dx.doi.org/10.3390/ijms232314823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736291/
https://www.ncbi.nlm.nih.gov/pubmed/36499150
http://dx.doi.org/10.3390/ijms232314823

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