1,2-Hydrogenation and Transhydrogenation Catalyzed by 3-Ketosteroid Δ(1)-Dehydrogenase from Sterolibacterium denitrificans—Kinetics, Isotope Labelling and QM:MM Modelling Studies

Bacteria and fungi that are able to metabolize steroids express 3-ketosteroid-Δ(1)-dehydrogenases (KstDs). KstDs such as AcmB form Sterolibacterium denitrificans Chol-1 catalyze the enantioselective 1α,2β-dehydrogenation of steroids to their desaturated analogues, e.g., the formation of 1,4-androsta...

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Detalles Bibliográficos
Autores principales: Wojtkiewicz, Agnieszka M., Glanowski, Michał, Waligórski, Piotr, Janeczko, Tomasz, Szaleniec, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736390/
https://www.ncbi.nlm.nih.gov/pubmed/36498984
http://dx.doi.org/10.3390/ijms232314660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736390/
https://www.ncbi.nlm.nih.gov/pubmed/36498984
http://dx.doi.org/10.3390/ijms232314660

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