Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis

The terminal nucleotidyltransferases TUT4 and TUT7 (TUT4/7) regulate miRNA and mRNA stability by 3′ end uridylation. In humans, TUT4/7 polyuridylates both mRNA and pre-miRNA, leading to degradation by the U-specific exonuclease DIS3L2. We investigate the role of uridylation-dependent decay in mainta...

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Detalles Bibliográficos
Autores principales: Zhang, Pengcheng, Frederick, Mallory I., Heinemann, Ilka U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736393/
https://www.ncbi.nlm.nih.gov/pubmed/36497000
http://dx.doi.org/10.3390/cells11233742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736393/
https://www.ncbi.nlm.nih.gov/pubmed/36497000
http://dx.doi.org/10.3390/cells11233742

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