Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism

Alpha-synuclein (aSyn) is a 14 kD protein encoded by the SNCA gene that is expressed in vertebrates and normally localizes to presynaptic terminals and the nucleus. aSyn forms pathological intracellular aggregates that typify a group of important neurodegenerative diseases called synucleinopathies....

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Detalles Bibliográficos
Autores principales: Weston, Leah J., Bowman, Anna M., Osterberg, Valerie R., Meshul, Charles K., Woltjer, Randall L., Unni, Vivek K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736441/
https://www.ncbi.nlm.nih.gov/pubmed/36499619
http://dx.doi.org/10.3390/ijms232315294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736441/
https://www.ncbi.nlm.nih.gov/pubmed/36499619
http://dx.doi.org/10.3390/ijms232315294

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