Synthesis of Functionalized Isoquinolone Derivatives via Rh(III)-Catalyzed [4+2]-Annulation of Benzamides with Internal Acetylene-Containing α-CF(3)-α-Amino Carboxylates

A convenient pathway to a new series of α-CF(3)-substituted α-amino acid derivatives bearing pharmacophore isoquinolone core in their backbone has been developed. The method is based on [4+2]-annulation of N-(pivaloyloxy) aryl amides with orthogonally protected internal acetylene-containing α-amino...

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Detalles Bibliográficos
Autores principales: Vorobyeva, Daria V., Petropavlovskikh, Dmitry A., Godovikov, Ivan A., Dolgushin, Fedor M., Osipov, Sergey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736582/
https://www.ncbi.nlm.nih.gov/pubmed/36500580
http://dx.doi.org/10.3390/molecules27238488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736582/
https://www.ncbi.nlm.nih.gov/pubmed/36500580
http://dx.doi.org/10.3390/molecules27238488

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