Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC

BACKGROUND: Both autophagy and glycolysis are essential for pancreatic ductal adenocarcinoma (PDAC) survival due to desmoplasia. We investigated whether targeting a hub gene which participates in both processes could be an efficient strategy for PDAC treatment. METHODS: The expression pattern of gly...

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Detalles Bibliográficos
Autores principales: Jiang, Yongsheng, Han, Lijie, Xue, Meilin, Wang, Ting, Zhu, Youwei, Xiong, Cheng, Shi, Minmin, Li, Hongzhe, Hai, Wangxi, Huo, Yanmiao, Shen, Baiyong, Jiang, Lingxi, Chen, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736795/
https://www.ncbi.nlm.nih.gov/pubmed/36495123
http://dx.doi.org/10.1002/ctm2.1126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736795/
https://www.ncbi.nlm.nih.gov/pubmed/36495123
http://dx.doi.org/10.1002/ctm2.1126

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