Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family

The PCTAIRE subfamily belongs to the CDK (cyclin-dependent kinase) family and represents an understudied class of kinases of the dark kinome. They exhibit a highly conserved binding pocket and are activated by cyclin Y binding. CDK16 is targeted to the plasma membrane after binding to N-myristoylate...

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Detalles Bibliográficos
Autores principales: Amrhein, Jennifer Alisa, Berger, Lena Marie, Tjaden, Amelie, Krämer, Andreas, Elson, Lewis, Tolvanen, Tuomas, Martinez-Molina, Daniel, Kaiser, Astrid, Schubert-Zsilavecz, Manfred, Müller, Susanne, Knapp, Stefan, Hanke, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736855/
https://www.ncbi.nlm.nih.gov/pubmed/36499165
http://dx.doi.org/10.3390/ijms232314834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736855/
https://www.ncbi.nlm.nih.gov/pubmed/36499165
http://dx.doi.org/10.3390/ijms232314834

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