Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling

Sphingosine kinase 1 (SPHK1) and the sphingosine-1-phosphate (S1P) signaling pathway have been shown to play a role in pulmonary arterial hypertension (PAH). S1P is an important stimulus for pulmonary artery smooth muscle cell (PASMC) proliferation and pulmonary vascular remodeling. We aimed to exam...

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Detalles Bibliográficos
Autores principales: Chen, Jiwang, Lockett, Angelia, Zhao, Shuangping, Huang, Long Shuang, Wang, Yifan, Wu, Weiwen, Tang, Ming, Haider, Shahzaib, Velez Rendon, Daniela, Khan, Raheel, Liu, Bing, Felesena, Nicholas, Sysol, Justin R., Valdez-Jasso, Daniela, Tang, Haiyang, Bai, Yang, Natarajan, Viswanathan, Machado, Roberto F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736859/
https://www.ncbi.nlm.nih.gov/pubmed/36498853
http://dx.doi.org/10.3390/ijms232314516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736859/
https://www.ncbi.nlm.nih.gov/pubmed/36498853
http://dx.doi.org/10.3390/ijms232314516

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