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Development of Hydroxamate Derivatives Containing a Pyrazoline Moiety as APN Inhibitors to Overcome Angiogenesis

Aminopeptidase N (APN) was closely associated with cancer invasion, metastasis, and angiogenesis. Therefore, APN inhibitors have attracted more and more attention of scientists as antitumor agents. In the current study, we designed, synthesized, and evaluated one new series of pyrazoline-based hydro...

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Detalles Bibliográficos
Autores principales: Liu, Yangyang, Zhao, Dongsheng, Zhang, Chenghua, Fang, Hui, Shen, Qingsitong, Wang, Zhixian, Cao, Jiangying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736874/
https://www.ncbi.nlm.nih.gov/pubmed/36500432
http://dx.doi.org/10.3390/molecules27238339