Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1

Targeting cancer metabolism has become one of the strategies for a rational anti-tumor therapy. However, cellular plasticity, driven by a major regulator of cellular growth and metabolism, mTORC1, often leads toward treatment resistance. Sestrin2, a stress-inducible protein, has been described as an...

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Detalles Bibliográficos
Autores principales: Blagojevic, Biljana, Almouhanna, Fadi, Poschet, Gernot, Wölfl, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736985/
https://www.ncbi.nlm.nih.gov/pubmed/36497120
http://dx.doi.org/10.3390/cells11233863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736985/
https://www.ncbi.nlm.nih.gov/pubmed/36497120
http://dx.doi.org/10.3390/cells11233863

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