Substituent-Dependent Divergent Synthesis of 2-(3-Amino-2,4-dicyanophenyl)pyrroles, Pyrrolyldienols and 3-Amino-1-acylethylidene-2-cyanopyrrolizines via Reaction of Acylethynylpyrroles with Malononitrile

An efficient method for the synthesis of pharmaceutically and high-tech prospective 2-(3-amino-2,4-dicyanophenyl)pyrroles (in up to 88% yield) via the reaction of easily available substituted acylethynylpyrroles with malononitrile has been developed. The reaction proceeds in the KOH/MeCN system at 0...

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Detalles Bibliográficos
Autores principales: Gotsko, Maxim D., Saliy, Ivan V., Ushakov, Igor A., Sobenina, Lyubov N., Trofimov, Boris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737003/
https://www.ncbi.nlm.nih.gov/pubmed/36500621
http://dx.doi.org/10.3390/molecules27238528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737003/
https://www.ncbi.nlm.nih.gov/pubmed/36500621
http://dx.doi.org/10.3390/molecules27238528

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