Cargando…

Targeting FTO Suppresses Pancreatic Carcinogenesis via Regulating Stem Cell Maintenance and EMT Pathway

SIMPLE SUMMARY: Current treatment strategies for pancreatic cancer (PC) yield poor survival outcomes. It is thus essential to identify factors that orchestrate pancreatic tumorigenesis and contribute to therapeutic resistance. Fat mass and obesity-associated protein (FTO) play a crucial role in deme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garg, Rachana, Melstrom, Laleh, Chen, Jianjun, He, Chuan, Goel, Ajay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737034/ https://www.ncbi.nlm.nih.gov/pubmed/36497402 http://dx.doi.org/10.3390/cancers14235919

Ejemplares similares

LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway
por: Xu, Yihui, et al.
Publicado: (2022)

Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT
por: Buhrmann, Constanze, et al.
Publicado: (2014)

Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors
por: Hindriksen, Sanne, et al.
Publicado: (2012)

An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis
por: Carbone, Carmine, et al.
Publicado: (2014)

Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemness-maintenance in residual pancreatic cancer
por: Aravindan, Sheeja, et al.
Publicado: (2015)

Comprehensive mutations analyses of FTO (fat mass and obesity-associated gene) and their effects on FTO’s substrate binding implicated in obesity
por: Kumar, Rakesh, et al.
Publicado: (2022)

EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells
por: Rodriguez-Aznar, Eva, et al.
Publicado: (2019)

Targeting FTO for cancer therapy and more
por: Qing, Ying, et al.
Publicado: (2021)

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters
por: Li, Junlin, et al.
Publicado: (2011)

Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells
por: Che, Mingtian, et al.
Publicado: (2020)

The roles of FOXM1 in pancreatic stem cells and carcinogenesis
por: Quan, Ming, et al.
Publicado: (2013)

Anti-Allergic Drug Suppressed Pancreatic Carcinogenesis via Down-Regulation of Cellular Proliferation
por: Kachi, Kenta, et al.
Publicado: (2021)

Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs
por: Takahashi, Motoko, et al.
Publicado: (2022)

Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer
por: Okuno, Keisuke, et al.
Publicado: (2022)

Critical Enzymatic Functions of FTO in Obesity and Cancer
por: Deng, Xiaolan, et al.
Publicado: (2018)

Corrigendum: Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer
por: Okuno, Keisuke, et al.
Publicado: (2022)

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling
por: Sun, Liankang, et al.
Publicado: (2018)

m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling
por: Zeng, Juan, et al.
Publicado: (2021)

The Role of Carcinogenesis-Related Biomarkers in the Wnt Pathway and Their Effects on Epithelial–Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma
por: Bai, Yunpeng, et al.
Publicado: (2020)

Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation
por: Ou, Baochi, et al.
Publicado: (2022)

GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway
por: Liu, Ying, et al.
Publicado: (2021)

EMT-Induced Stemness and Tumorigenicity Are Fueled by the EGFR/Ras Pathway
por: Voon, Dominic Chih-Cheng, et al.
Publicado: (2013)

MicroRNA–Gene Interactions Impacted by Toxic Metal(oid)s during EMT and Carcinogenesis
por: Tran, Franklin, et al.
Publicado: (2022)

UNC13C Suppress Tumor Progression via Inhibiting EMT Pathway and Improves Survival in Oral Squamous Cell Carcinoma
por: Velmurugan, Bharath Kumar, et al.
Publicado: (2019)

RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis
por: Karunanithi, Sheelarani, et al.
Publicado: (2017)

Mammary stem cells, self-renewal pathways, and carcinogenesis
por: Liu, Suling, et al.
Publicado: (2005)

Colorectal Advanced Neoplasms Occur through Dual Carcinogenesis Pathways in Individuals with Coexisting Serrated Polyps
por: Yamada, Atsushi, et al.
Publicado: (2014)

EMT and Treatment Resistance in Pancreatic Cancer
por: Gaianigo, Nicola, et al.
Publicado: (2017)

Targeting fat mass and obesity-associated protein mitigates human colorectal cancer growth in vitro and in a murine model
por: Phan, Thuy, et al.
Publicado: (2023)

TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells
por: Wu, Jian, et al.
Publicado: (2019)

IER3 in pancreatic carcinogenesis
por: Molejon, Maria Inés, et al.
Publicado: (2015)

EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway
por: Wang, Yuanyang, et al.
Publicado: (2023)

Early vs. Late Chemoradiation Therapy and the Postoperative Interval to Adjuvant Therapy Do Not Correspond to Local Recurrence in Resected Pancreatic Cancer
por: Patel, Ajay A, et al.
Publicado: (2015)

Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer
por: Ma, Yanmei, et al.
Publicado: (2021)

Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer
por: Ma, Yanmei, et al.
Publicado: (2022)

Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway
por: Ding, Yongzeng, et al.
Publicado: (2018)

Retraction Notice to: m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling
por: Zeng, Juan, et al.
Publicado: (2022)

Pharmacological Inhibition of FTO
por: McMurray, Fiona, et al.
Publicado: (2015)

Inhibition of Bone Morphogenetic Protein 2 Suppresses the Stemness Maintenance of Cancer Stem Cells in Hepatocellular Carcinoma via the MAPK/ERK Pathway
por: Guo, Juncheng, et al.
Publicado: (2021)

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives
por: Faheem, Mir Mohd, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cond0je8s4rk567h4js6e046i8