Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of New Drugs against Human Topoisomerase I Receptor

Human Topoisomerase I (hTop1p) is a ubiquitous enzyme that relaxes supercoiled DNA through a conserved mechanism involving transient breakage, rotation, and binding. Htop1p is the molecular target of the chemotherapeutic drug camptothecin (CPT). It causes the hTop1p-DNA complex to slow down the bind...

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Detalles Bibliográficos
Autores principales: Madeddu, Francesco, Di Martino, Jessica, Pieroni, Michele, Del Buono, Davide, Bottoni, Paolo, Botta, Lorenzo, Castrignanò, Tiziana, Saladino, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737192/
https://www.ncbi.nlm.nih.gov/pubmed/36498979
http://dx.doi.org/10.3390/ijms232314652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737192/
https://www.ncbi.nlm.nih.gov/pubmed/36498979
http://dx.doi.org/10.3390/ijms232314652

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