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Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of New Drugs against Human Topoisomerase I Receptor

Human Topoisomerase I (hTop1p) is a ubiquitous enzyme that relaxes supercoiled DNA through a conserved mechanism involving transient breakage, rotation, and binding. Htop1p is the molecular target of the chemotherapeutic drug camptothecin (CPT). It causes the hTop1p-DNA complex to slow down the bind...

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Detalles Bibliográficos
Autores principales:	Madeddu, Francesco, Di Martino, Jessica, Pieroni, Michele, Del Buono, Davide, Bottoni, Paolo, Botta, Lorenzo, Castrignanò, Tiziana, Saladino, Raffaele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737192/ https://www.ncbi.nlm.nih.gov/pubmed/36498979 http://dx.doi.org/10.3390/ijms232314652

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