Quantification of Tafenoquine and 5,6-Orthoquinone Tafenoquine by UHPLC-MS/MS in Blood, Plasma, and Urine, and Application to a Pharmacokinetic Study

Analytical methods for the quantification of the new 8-aminoquinoline antimalarial tafenoquine (TQ) in human blood, plasma and urine, and the 5,6-orthoquinone tafenoquine metabolite (5,6-OQTQ) in human plasma and urine have been validated. The procedure involved acetonitrile extraction of samples fo...

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Detalles Bibliográficos
Autores principales: Birrell, Geoffrey W., Van Breda, Karin, Barber, Bridget, Webster, Rebecca, McCarthy, James S., Shanks, G. Dennis, Edstein, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737280/
https://www.ncbi.nlm.nih.gov/pubmed/36500278
http://dx.doi.org/10.3390/molecules27238186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737280/
https://www.ncbi.nlm.nih.gov/pubmed/36500278
http://dx.doi.org/10.3390/molecules27238186

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