Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity

Type 1 diabetes is a polygenic disease that results in an autoimmune response directed against insulin-producing beta cells. PTPN2 is a known high-risk type 1 diabetes associated gene expressed in both immune- and pancreatic beta cells, but how genes affect the development of autoimmune diabetes is...

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Detalles Bibliográficos
Autores principales: Triolo, Taylor M., Matuschek, J. Quinn, Castro-Gutierrez, Roberto, Shilleh, Ali H., Williams, Shane P. M., Hansen, Maria S., McDaniel, Kristen, Barra, Jessie M., Michels, Aaron, Russ, Holger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737324/
https://www.ncbi.nlm.nih.gov/pubmed/36497105
http://dx.doi.org/10.3390/cells11233845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737324/
https://www.ncbi.nlm.nih.gov/pubmed/36497105
http://dx.doi.org/10.3390/cells11233845

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