Cargando…

Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity

Type 1 diabetes is a polygenic disease that results in an autoimmune response directed against insulin-producing beta cells. PTPN2 is a known high-risk type 1 diabetes associated gene expressed in both immune- and pancreatic beta cells, but how genes affect the development of autoimmune diabetes is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Triolo, Taylor M., Matuschek, J. Quinn, Castro-Gutierrez, Roberto, Shilleh, Ali H., Williams, Shane P. M., Hansen, Maria S., McDaniel, Kristen, Barra, Jessie M., Michels, Aaron, Russ, Holger A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737324/ https://www.ncbi.nlm.nih.gov/pubmed/36497105 http://dx.doi.org/10.3390/cells11233845

Ejemplares similares

Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
por: Shilleh, Ali H., et al.
Publicado: (2023)

Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells
por: Shilleh, Ali H., et al.
Publicado: (2023)

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro
por: Docherty, Fiona M., et al.
Publicado: (2021)

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses
por: Ventura, Pedro M O, et al.
Publicado: (2022)

Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression
por: Zhang, Jingru, et al.
Publicado: (2023)

Display of the HIV envelope protein at the yeast cell surface for immunogen development
por: Mathew, Elizabeth, et al.
Publicado: (2018)

Gold Nanoclusters Display Low Immunogenic Effect in Microglia Cells
por: Sobska, Joanna, et al.
Publicado: (2021)

Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition
por: Castro-Gutierrez, Roberto, et al.
Publicado: (2021)

Adiponectin Knockout Mice Display Cognitive and Synaptic Deficits
por: Bloemer, Jenna, et al.
Publicado: (2019)

Most viral peptides displayed by class I MHC on infected cells are immunogenic
por: Croft, Nathan P., et al.
Publicado: (2019)

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
por: Baumgartner, Christina K., et al.
Publicado: (2023)

The FERM and PDZ Domain-Containing Protein Tyrosine Phosphatases, PTPN4 and PTPN3, Are Both Dispensable for T Cell Receptor Signal Transduction
por: Bauler, Timothy J., et al.
Publicado: (2008)

Methylation and expression of PTPN22 in esophageal squamous cell carcinoma
por: Deng, Jiaying, et al.
Publicado: (2016)

Redoxing PTPN22 activity
por: Shumanska, Magdalena, et al.
Publicado: (2022)

Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma
por: Jin, Yi, et al.
Publicado: (2020)

PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness
por: Hamyeh, Mohamed, et al.
Publicado: (2020)

Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8(+) T cells in skin
por: Hochheiser, Katharina, et al.
Publicado: (2021)

PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis
por: Chang, Hui-Hsin, et al.
Publicado: (2012)

Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease
por: Sharp, Robert C., et al.
Publicado: (2015)

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
por: James, Jaime, et al.
Publicado: (2022)

Baculovirus Surface Display of Immunogenic Proteins for Vaccine Development
por: Premanand, Balraj, et al.
Publicado: (2018)

Chemically augmented malaria sporozoites display an altered immunogenic profile
por: Duszenko, Nikolas, et al.
Publicado: (2023)

PTPN4 negatively regulates CrkI in human cell lines
por: Zhou, Juan, et al.
Publicado: (2013)

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence
por: Griger, Joscha, et al.
Publicado: (2017)

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells
por: Clarke, Fiona, et al.
Publicado: (2017)

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens
por: Kar, Uddipan, et al.
Publicado: (2022)

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells
por: Flosbach, Markus, et al.
Publicado: (2020)

Triple-Knockout, Synuclein-Free Mice Display Compromised Lipid Pattern
por: Guschina, Irina A., et al.
Publicado: (2021)

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification
por: Wiede, Florian, et al.
Publicado: (2017)

Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration
por: Po’uha, Sela T., et al.
Publicado: (2019)

Identification of Novel Immunogenic Proteins of Neisseria gonorrhoeae by Phage Display
por: Connor, Daniel O., et al.
Publicado: (2016)

Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction
por: Agrud, Anass, et al.
Publicado: (2022)

Motorless cadence control of standard and low duty cycle-patterned neural stimulation intensity extends muscle-driven cycling output after paralysis
por: Gelenitis, Kristen, et al.
Publicado: (2022)

Yeast surface display of HIV Env protein variants for the discovery of novel vaccine immunogens
por: Grimm, S, et al.
Publicado: (2012)

Modeling the effect of PTPN22 in rheumatoid arthritis
por: Bourgey, Mathieu, et al.
Publicado: (2007)

BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders
por: Qiu, Peiyuan, et al.
Publicado: (2019)

Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure
por: Vilca, Samara, et al.
Publicado: (2023)

Comprehensive analysis of PTPN gene family revealing PTPN7 as a novel biomarker for immuno-hot tumors in breast cancer
por: Wang, Fengxu, et al.
Publicado: (2022)

M(4 )muscarinic receptor knockout mice display abnormal social behavior and decreased prepulse inhibition
por: Koshimizu, Hisatsugu, et al.
Publicado: (2012)

HDAC10 promotes angiogenesis in endothelial cells through the PTPN22/ERK axis
por: Duan, Baoyu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mjpvo20jb927lgvluqq193l8rf