CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop

The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies. T cells redirected for universal cytokine-mediated killing (TRUCKs), commonly referred to as “fourth generation” CAR T...

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Detalles Bibliográficos
Autores principales: Harrer, Dennis Christoph, Schenkel, Charlotte, Bezler, Valerie, Kaljanac, Marcell, Hartley, Jordan, Barden, Markus, Pan, Hong, Holzinger, Astrid, Herr, Wolfgang, Abken, Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737386/
https://www.ncbi.nlm.nih.gov/pubmed/36497099
http://dx.doi.org/10.3390/cells11233839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737386/
https://www.ncbi.nlm.nih.gov/pubmed/36497099
http://dx.doi.org/10.3390/cells11233839

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