Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) commonly possesses chronical elevation of IRE1α-ASK1 signaling. Orphan nuclear receptor Nur77, a promising therapeutic target in various cancer types, is frequently silenced in HCC. In this study, we show that cryptomeridiol (Bkh126), a naturally occurring sesquiterpen...

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Detalles Bibliográficos
Autores principales: Li, Xudan, Chen, Quancheng, Liu, Jie, Lai, Shenjin, Zhang, Minda, Zhen, Tidong, Hu, Hongyu, Gao, Xiang, Wong, Alice S. T., Zeng, Jin-Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737475/
https://www.ncbi.nlm.nih.gov/pubmed/36497127
http://dx.doi.org/10.3390/cells11233870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737475/
https://www.ncbi.nlm.nih.gov/pubmed/36497127
http://dx.doi.org/10.3390/cells11233870

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