Facile Synthesis of Some Coumarin Derivatives and Their Cytotoxicity through VEGFR2 and Topoisomerase II Inhibition

Novel semisynthetic coumarin derivatives were synthesized to be developed as chemotherapeutic anticancer agents through topoisomerase II, VEGFR2 inhibition that leads to apoptotic cancer cell death. The coumarin amino acids and dipeptides derivatives were prepared by the reaction of coumarin-3-carbo...

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Detalles Bibliográficos
Autores principales: Gomaa, Mohamed S., Ali, Ibrahim A. I., El Enany, Gaber, El Ashry, El Sayed H., El Rayes, Samir M., Fathalla, Walid, Ahmed, Abdulghany H. A., Abubshait, Samar A., Abubshait, Haya A., Nafie, Mohamed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737644/
https://www.ncbi.nlm.nih.gov/pubmed/36500372
http://dx.doi.org/10.3390/molecules27238279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737644/
https://www.ncbi.nlm.nih.gov/pubmed/36500372
http://dx.doi.org/10.3390/molecules27238279

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