Human Milk Oligosaccharide 2′-Fucosyllactose Inhibits Ligand Binding to C-Type Lectin DC-SIGN but Not to Langerin

Human milk oligosaccharides (HMOs) and their most abundant component, 2′-Fucosyllactose (2′-FL), are known to be immunomodulatory. Previously, it was shown that HMOs and 2′-FL bind to the C-type lectin receptor DC-SIGN. Here we show, using a ligand-receptor competition assay, that a whole mixture of...

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Detalles Bibliográficos
Autores principales: Mukherjee, Reshmi, Somovilla, Victor J., Chiodo, Fabrizio, Bruijns, Sven, Pieters, Roland J., Garssen, Johan, van Kooyk, Yvette, Kraneveld, Aletta D., van Bergenhenegouwen, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737664/
https://www.ncbi.nlm.nih.gov/pubmed/36499067
http://dx.doi.org/10.3390/ijms232314745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737664/
https://www.ncbi.nlm.nih.gov/pubmed/36499067
http://dx.doi.org/10.3390/ijms232314745

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