Quantification of Paeoniflorin by Fully Validated LC–MS/MS Method: Its Application to Pharmacokinetic Interaction between Paeoniflorin and Verapamil

A rapid, sensitive, and specific LC-MS/MS method was developed and fully validated for the detection of paeoniflorin only in rat plasma, and applied to pharmacokinetic studies, including intravenous, multi-dose oral and combined administrations with verapamil. In this study, tolbutamide was used as...

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Detalles Bibliográficos
Autores principales: Bao, Bin, Zhao, Yonglin, Gong, Huan, Shi, Songshan, Wang, Huijun, Wang, Shunchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737983/
https://www.ncbi.nlm.nih.gov/pubmed/36500431
http://dx.doi.org/10.3390/molecules27238337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9737983/
https://www.ncbi.nlm.nih.gov/pubmed/36500431
http://dx.doi.org/10.3390/molecules27238337

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