CD70-Targeted Micelles Enhance HIF2α siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells

The majority of clear cell renal cell carcinomas (ccRCCs) are characterized by mutations in the Von Hippel–Lindau (VHL) tumor suppressor gene, which leads to the stabilization and accumulation of the HIF2α transcription factor that upregulates key oncogenic pathways that promote glucose metabolism,...

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Detalles Bibliográficos
Autores principales: Trac, Noah, Oh, Hyun Seok, Jones, Leila Izzy, Caliliw, Randy, Ohtake, Shinji, Shuch, Brian, Chung, Eun Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738223/
https://www.ncbi.nlm.nih.gov/pubmed/36500549
http://dx.doi.org/10.3390/molecules27238457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738223/
https://www.ncbi.nlm.nih.gov/pubmed/36500549
http://dx.doi.org/10.3390/molecules27238457

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