TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

The survival of patients with glioblastoma (GBM) is poor. The main cause is the presence of glioma stem cells (GSCs), exceptionally resistant to temozolomide (TMZ) treatment. This last may be related to the heterogeneous expression of ion channels, among them TRPML2. Its mRNA expression was evaluate...

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Detalles Bibliográficos
Autores principales: Morelli, Maria Beatrice, Nabissi, Massimo, Amantini, Consuelo, Maggi, Federica, Ricci-Vitiani, Lucia, Pallini, Roberto, Santoni, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738251/
https://www.ncbi.nlm.nih.gov/pubmed/36499683
http://dx.doi.org/10.3390/ijms232315356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738251/
https://www.ncbi.nlm.nih.gov/pubmed/36499683
http://dx.doi.org/10.3390/ijms232315356

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