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TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients
The survival of patients with glioblastoma (GBM) is poor. The main cause is the presence of glioma stem cells (GSCs), exceptionally resistant to temozolomide (TMZ) treatment. This last may be related to the heterogeneous expression of ion channels, among them TRPML2. Its mRNA expression was evaluate...
Autores principales: | Morelli, Maria Beatrice, Nabissi, Massimo, Amantini, Consuelo, Maggi, Federica, Ricci-Vitiani, Lucia, Pallini, Roberto, Santoni, Giorgio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738251/ https://www.ncbi.nlm.nih.gov/pubmed/36499683 http://dx.doi.org/10.3390/ijms232315356 |
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