Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells

Despite the high morbidity and mortality rates associated with colorectal cancer (CRC), the underlying molecular mechanisms driving CRC development remain largely uncharacterized. Chromosome instability (CIN), or ongoing changes in chromosome complements, occurs in ~85% of CRCs and is a proposed dri...

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Detalles Bibliográficos
Autores principales: Neudorf, Nicole M., Thompson, Laura L., Lichtensztejn, Zelda, Razi, Tooba, McManus, Kirk J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738323/
https://www.ncbi.nlm.nih.gov/pubmed/36496990
http://dx.doi.org/10.3390/cells11233731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738323/
https://www.ncbi.nlm.nih.gov/pubmed/36496990
http://dx.doi.org/10.3390/cells11233731

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