Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia

Type 1 spinocerebellar ataxia (SCA1) is a progressive neurodegenerative disorder with no effective treatment to date. Using mice modeling SCA1, it has been demonstrated that a drug that amplifies mGlu1 receptor activation (mGlu1 receptor PAM, Ro0711401) improves motor coordination without the develo...

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Detalles Bibliográficos
Autores principales: Liberatore, Francesca, Antenucci, Nico, Tortolani, Daniel, Mascio, Giada, Fanti, Federico, Sergi, Manuel, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando, Maccarrone, Mauro, Notartomaso, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738505/
https://www.ncbi.nlm.nih.gov/pubmed/36497172
http://dx.doi.org/10.3390/cells11233916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738505/
https://www.ncbi.nlm.nih.gov/pubmed/36497172
http://dx.doi.org/10.3390/cells11233916

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