Cargando…

Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein

By binding to the spliceosomal protein Snu66, the human ubiquitin-like protein Hub1 is a modulator of the spliceosome performance and facilitates alternative splicing. Small molecules that bind to Hub1 would be of interest to study the protein-protein interaction of Hub1/Snu66, which is linked to se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reyes Romero, Atilio, Kubica, Katarzyna, Kitel, Radoslaw, Rodríguez, Ismael, Magiera-Mularz, Katarzyna, Dömling, Alexander, Holak, Tad A., Surmiak, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738620/ https://www.ncbi.nlm.nih.gov/pubmed/36500376 http://dx.doi.org/10.3390/molecules27238282

Ejemplares similares

Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments
por: Kitel, Radoslaw, et al.
Publicado: (2022)

PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action
por: Surmiak, Ewa, et al.
Publicado: (2021)

Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction
por: Muszak, Damian, et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists
por: Butera, Roberto, et al.
Publicado: (2021)

Competition NMR for Detection of Hit/Lead Inhibitors of Protein–Protein Interactions
por: Musielak, Bogdan, et al.
Publicado: (2020)

Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction
por: Shaabani, Shabnam, et al.
Publicado: (2022)

CA-170 – A Potent Small-Molecule PD-L1 Inhibitor or Not?
por: Musielak, Bogdan, et al.
Publicado: (2019)

Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint
por: Konieczny, Magdalena, et al.
Publicado: (2020)

Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies
por: Rodriguez, Ismael, et al.
Publicado: (2023)

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells
por: Skalniak, Lukasz, et al.
Publicado: (2017)

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)
por: Zak, Krzysztof M., et al.
Publicado: (2016)

Human and mouse PD-L1: similar molecular structure, but different druggability profiles
por: Magiera-Mularz, Katarzyna, et al.
Publicado: (2020)

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists
por: Neochoritis, Constantinos G, et al.
Publicado: (2019)

Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G(0)/G(1) Arrest by Inhibiting Deubiquitinase USP2a
por: Magiera, Katarzyna, et al.
Publicado: (2017)

Development of the Inhibitors That Target the PD-1/PD-L1 Interaction—A Brief Look at Progress on Small Molecules, Peptides and Macrocycles
por: Guzik, Katarzyna, et al.
Publicado: (2019)

Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists
por: Kocik, Justyna, et al.
Publicado: (2019)

Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors
por: Ważyńska, Marta A., et al.
Publicado: (2023)

A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
por: Reyes Romero, Atilio, et al.
Publicado: (2021)

Analysis tools for single-monomer measurements of self-assembly processes
por: Hoyer, Maria, et al.
Publicado: (2022)

Fragment-Based Library Generation for the Discovery of a Peptidomimetic p53-Mdm4 Inhibitor
por: Boltjes, André, et al.
Publicado: (2014)

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists
por: Koes, David, et al.
Publicado: (2012)

The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells
por: Ammon, Tim, et al.
Publicado: (2014)

Artificial Macrocycles as Potent p53–MDM2 Inhibitors
por: Estrada-Ortiz, Natalia, et al.
Publicado: (2017)

Effect of Selected Silyl Groups on the Anticancer Activity of 3,4-Dibromo-5-Hydroxy-Furan-2(5H)-One Derivatives
por: Kitel, Radoslaw, et al.
Publicado: (2021)

In Silico Design and Selection of New Tetrahydroisoquinoline-Based CD44 Antagonist Candidates
por: Ruiz-Moreno, Angel J., et al.
Publicado: (2021)

‘Chemistry at the speed of sound’: automated 1536-well nanoscale synthesis of 16 scaffolds in parallel
por: Gao, Li, et al.
Publicado: (2023)

Correction: ‘Chemistry at the speed of sound’: automated 1536-well nanoscale synthesis of 16 scaffolds in parallel
por: Gao, Li, et al.
Publicado: (2023)

Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe
por: Malicki, Stanisław, et al.
Publicado: (2022)

Benchmark of Generic Shapes for Macrocycles
por: Reyes Romero, Atilio, et al.
Publicado: (2020)

Correction to “Benchmark of Generic Shapes for Macrocycles”
por: Reyes Romero, Atilio, et al.
Publicado: (2021)

Computer-Aided Design of Fragment Mixtures for NMR-Based Screening
por: Arroyo, Xavier, et al.
Publicado: (2013)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

Synthesis and Cytotoxicity of 2,3-Enopyranosyl C-Linked Conjugates of Genistein
por: Szeja, Wieslaw, et al.
Publicado: (2014)

NMR of paramagnetic molecules
por: Berliner, Lawrence J, et al.
Publicado: (1993)

Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities
por: Huang, Yijun, et al.
Publicado: (2014)

Multicomponent Macrocyclic IL-17a Modifier
por: Abdelraheem, Eman, et al.
Publicado: (2022)

Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis
por: Zyla, Edyta, et al.
Publicado: (2021)

Changes in Performance and Morning‐Measured Responses in Sport Rock Climbers
por: Magiera, Artur, et al.
Publicado: (2019)

Computer-aided therapeutic diagnosis for anorexia
por: Spinczyk, Dominik, et al.
Publicado: (2020)

Computing hubs in the hippocampus and cortex
por: Clawson, Wesley, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gufv8u7c50kmeh2roe6n2qrbma