Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3

Progerin, a permanently farnesylated prelamin A protein in cell nuclei, is potentially implicated in the defenestration of liver sinusoidal endothelial cells (LSECs) and liver fibrogenesis. Autophagy regulates the degradation of nuclear components, called nucleophagy, in response to damage. However,...

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Detalles Bibliográficos
Autores principales: Bai, Yangqiu, Liu, Jinying, Jiang, Xiaoke, Li, Xiuling, Zhang, Bingyong, Luo, Xiaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738635/
https://www.ncbi.nlm.nih.gov/pubmed/36497176
http://dx.doi.org/10.3390/cells11233918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738635/
https://www.ncbi.nlm.nih.gov/pubmed/36497176
http://dx.doi.org/10.3390/cells11233918

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