Cholesterol Stationary Phase in the Separation and Identification of siRNA Impurities by Two-Dimensional Liquid Chromatography-Mass Spectrometry

The aim of this research was to develop a simple and efficient ion-pair reagent-free chromatographic method for the separation and qualitative determination of oligonucleotide impurities, exemplified by synthesis of raw products of the two single strands of patisiran siRNA. The stationary phases wit...

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Detalles Bibliográficos
Autores principales: Studzińska, Sylwia, Li, Feiyang, Szumski, Michał, Buszewski, Bogusław, Lämmerhofer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738757/
https://www.ncbi.nlm.nih.gov/pubmed/36499291
http://dx.doi.org/10.3390/ijms232314960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738757/
https://www.ncbi.nlm.nih.gov/pubmed/36499291
http://dx.doi.org/10.3390/ijms232314960

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