Nucleoside Analogs and Perylene Derivatives Modulate Phase Separation of SARS-CoV-2 N Protein and Genomic RNA In Vitro

The life cycle of severe acute respiratory syndrome coronavirus 2 includes several steps that are supposedly mediated by liquid–liquid phase separation (LLPS) of the viral nucleocapsid protein (N) and genomic RNA. To facilitate the rational design of LLPS-targeting therapeutics, we modeled N-RNA bio...

Descripción completa

Detalles Bibliográficos
Autores principales: Svetlova, Julia, Knizhnik, Ekaterina, Manuvera, Valentin, Severov, Vyacheslav, Shirokov, Dmitriy, Grafskaia, Ekaterina, Bobrovsky, Pavel, Matyugina, Elena, Khandazhinskaya, Anastasia, Kozlovskaya, Liubov, Miropolskaya, Nataliya, Aralov, Andrey, Khodarovich, Yuri, Tsvetkov, Vladimir, Kochetkov, Sergey, Lazarev, Vassili, Varizhuk, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738865/
https://www.ncbi.nlm.nih.gov/pubmed/36499608
http://dx.doi.org/10.3390/ijms232315281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738865/
https://www.ncbi.nlm.nih.gov/pubmed/36499608
http://dx.doi.org/10.3390/ijms232315281

Ejemplares similares