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Opposing Roles of DCs and iNKT Cells in the Induction of Foxp3 Expression by MLN CD25(+)CD4(+) T Cells during IFNγ-Driven Colitis

We have previously shown that a deficiency of CD1d-restricted invariant natural killer T (iNKT) cells exacerbates dextran sulfate sodium (DSS)-induced colitis in Yeti mice that exhibit IFNγ-mediated hyper-inflammation. Although iNKT cell-deficiency resulted in reduced Foxp3 expression by mesenteric...

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Detalles Bibliográficos
Autores principales: Lee, Sung Won, Park, Hyun Jung, Van Kaer, Luc, Hong, Seokmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738888/
https://www.ncbi.nlm.nih.gov/pubmed/36499642
http://dx.doi.org/10.3390/ijms232315316