Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation

α-Synuclein (α-Syn) aggregates are implicated in Parkinson’s disease (PD), so inhibitors of α-Syn aggregation have been intensively explored. It has been demonstrated that small molecules might be able to reduce α-Syn aggregation in fibrils, thus exerting neuroprotective effects in models of PD. To...

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Detalles Bibliográficos
Autores principales: De Luca, Laura, Vittorio, Serena, Peña-Díaz, Samuel, Pitasi, Giovanna, Fornt-Suñé, Marc, Bucolo, Federica, Ventura, Salvador, Gitto, Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738895/
https://www.ncbi.nlm.nih.gov/pubmed/36499173
http://dx.doi.org/10.3390/ijms232314844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738895/
https://www.ncbi.nlm.nih.gov/pubmed/36499173
http://dx.doi.org/10.3390/ijms232314844

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