The Use of Aryl-Substituted Homophthalic Anhydrides in the Castagnoli–Cushman Reaction Provides Access to Novel Tetrahydroisoquinolone Carboxylic Acid Bearing an All-Carbon Quaternary Stereogenic Center

Novel aryl-substituted homophthalic acids were cyclodehydrated to the respective homophthalic anhydrides for use in the Castagnoli–Cushman reaction. With a range of imines, this reaction proceeded smoothly and delivered hitherto undescribed 4-aryl-substituted tetrahydroisoquinolonic acids with remar...

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Detalles Bibliográficos
Autores principales: Moshnenko, Nazar, Kazantsev, Alexander, Bakulina, Olga, Dar’in, Dmitry, Krasavin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738897/
https://www.ncbi.nlm.nih.gov/pubmed/36500582
http://dx.doi.org/10.3390/molecules27238462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9738897/
https://www.ncbi.nlm.nih.gov/pubmed/36500582
http://dx.doi.org/10.3390/molecules27238462

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