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TFAM’s Contributions to mtDNA Replication and OXPHOS Biogenesis Are Genetically Separable

The ability of animal orthologs of human mitochondrial transcription factor A (hTFAM) to support the replication of human mitochondrial DNA (hmtDNA) does not follow a simple pattern of phylogenetic closeness or sequence similarity. In particular, TFAM from chickens (Gallus gallus, chTFAM), unlike TF...

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Detalles Bibliográficos
Autores principales: Kozhukhar, Natalya, Alexeyev, Mikhail F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739059/
https://www.ncbi.nlm.nih.gov/pubmed/36497015
http://dx.doi.org/10.3390/cells11233754