Design Two Novel Tetrahydroquinoline Derivatives against Anticancer Target LSD1 with 3D-QSAR Model and Molecular Simulation

Lysine-specific demethylase 1 (LSD1) is a histone-modifying enzyme, which is a significant target for anticancer drug research. In this work, 40 reported tetrahydroquinoline-derivative inhibitors targeting LSD1 were studied to establish the three-dimensional quantitative structure–activity relations...

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Detalles Bibliográficos
Autores principales: Xu, Yongtao, Fan, Baoyi, Gao, Yunlong, Chen, Yifan, Han, Di, Lu, Jiarui, Liu, Taigang, Gao, Qinghe, Zhang, John Zenghui, Wang, Meiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739212/
https://www.ncbi.nlm.nih.gov/pubmed/36500451
http://dx.doi.org/10.3390/molecules27238358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739212/
https://www.ncbi.nlm.nih.gov/pubmed/36500451
http://dx.doi.org/10.3390/molecules27238358

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