Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration

When WWOX is downregulated in middle age, aggregation of a protein cascade, including TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more than 30 years, which results in amyloid precursor protein (APP) degradation, amyloid beta (Aβ) generation, and neurodegeneration,...

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Detalles Bibliográficos
Autores principales: Lin, Yu-Hao, Shih, Yao-Hsiang, Yap, Ye Vone, Chen, Yen-Wei, Kuo, Hsiang-Lin, Liu, Tsung-Yun, Hsu, Li-Jin, Kuo, Yu-Min, Chang, Nan-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739312/
https://www.ncbi.nlm.nih.gov/pubmed/36498839
http://dx.doi.org/10.3390/ijms232314510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739312/
https://www.ncbi.nlm.nih.gov/pubmed/36498839
http://dx.doi.org/10.3390/ijms232314510

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