Cargando…

Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration

When WWOX is downregulated in middle age, aggregation of a protein cascade, including TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more than 30 years, which results in amyloid precursor protein (APP) degradation, amyloid beta (Aβ) generation, and neurodegeneration,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Yu-Hao, Shih, Yao-Hsiang, Yap, Ye Vone, Chen, Yen-Wei, Kuo, Hsiang-Lin, Liu, Tsung-Yun, Hsu, Li-Jin, Kuo, Yu-Min, Chang, Nan-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739312/ https://www.ncbi.nlm.nih.gov/pubmed/36498839 http://dx.doi.org/10.3390/ijms232314510

Ejemplares similares

Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation
por: Lee, Ming-Hui, et al.
Publicado: (2017)

Zfra is a small wizard in the mitochondrial apoptosis
por: Dudekula, Subhan, et al.
Publicado: (2010)

Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo
por: Su, Wan-Pei, et al.
Publicado: (2020)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain
por: Chang, Jean-Yun, et al.
Publicado: (2015)

Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1
por: Zhang, Caiyun, et al.
Publicado: (2020)

Zfra activates memory Hyal-2+ CD3− CD19− spleen cells to block cancer growth, stemness, and metastasis in vivo
por: Lee, Ming-Hui, et al.
Publicado: (2015)

The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT and TRAPPC9-Associated Congenital Intellectual Disability
por: Zong, Min, et al.
Publicado: (2011)

HYAL-2–WWOX–SMAD4 Signaling in Cell Death and Anticancer Response
por: Hsu, Li-Jin, et al.
Publicado: (2016)

Congenital muscular dystrophy with fatty liver and infantile-onset cataract caused by TRAPPC11 mutations: broadening of the phenotype
por: Liang, Wen-Chen, et al.
Publicado: (2015)

Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response
por: Hong, Qunying, et al.
Publicado: (2007)

Mitotic transformation of TRAMM/TrappC12
por: Milev, Miroslav P., et al.
Publicado: (2015)

WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis
por: Chang, J-Y, et al.
Publicado: (2015)

trappc11 is required for protein glycosylation in zebrafish and humans
por: DeRossi, Charles, et al.
Publicado: (2016)

Trappc9 Deficiency Impairs the Plasticity of Stem Cells
por: Usman, Muhammad, et al.
Publicado: (2022)

Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson’s disease
por: Wu, Kuo-Jen, et al.
Publicado: (2023)

TRAPPC9 deficiency’s implication in “secondary” autism spectrum disorders
por: Majdoub, F., et al.
Publicado: (2023)

Novel TRAPPC11 Mutations in a Chinese Pedigree of Limb Girdle Muscular Dystrophy
por: Wang, Xike, et al.
Publicado: (2018)

Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking
por: Zhu, Pengyang, et al.
Publicado: (2016)

TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
por: Ren, Yimeng, et al.
Publicado: (2021)

Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice
por: Hu, Min, et al.
Publicado: (2023)

TRAPPC9 Mediates the Interaction between p150(Glued) and COPII Vesicles at the Target Membrane
por: Zong, Min, et al.
Publicado: (2012)

Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity
por: Liang, Zhengzheng S., et al.
Publicado: (2020)

Comprehensive Analysis and Risk Identification of Pulmonary Cryptococcosis in Non-HIV Patients
por: Lin, Chun, et al.
Publicado: (2021)

MCT4 Promotes Hepatocellular Carcinoma Progression by Upregulating TRAPPC5 Gene
por: Niu, Zheyu, et al.
Publicado: (2022)

Infection in Advanced Chronic Kidney Disease and Subsequent Adverse Outcomes after Dialysis Initiation: A Nationwide Cohort Study
por: Chang, Chih-Hsiang, et al.
Publicado: (2020)

Two Interrogated FBG Spectral Linewidth for Strain Sensing through Correlation
por: Hsu, Shih-Hsiang, et al.
Publicado: (2017)

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats
por: Lo, Shih-Hsiang, et al.
Publicado: (2017)

Dynamical characteristics of AC-driven hybrid WSe(2) monolayer/AlGaInP quantum wells light-emitting device
por: Konthoujam, James Singh, et al.
Publicado: (2023)

WWOX and Its Binding Proteins in Neurodegeneration
por: Hsu, Che-Yu, et al.
Publicado: (2021)

Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling
por: Zhang, Yonggang, et al.
Publicado: (2015)

Mycobacterium tuberculosis DNA Detection Using Surface Plasmon Resonance Modulated by Telecommunication Wavelength
por: Hsu, Shih-Hsiang, et al.
Publicado: (2013)

Multicolor Emission from Ultraviolet GaN-Based Photonic Quasicrystal Nanopyramid Structure with Semipolar In(x)Ga(1−x)N/GaN Multiple Quantum Wells
por: Chen, Cheng-Chang, et al.
Publicado: (2021)

Identification of TRAPPC8 as a Host Factor Required for Human Papillomavirus Cell Entry
por: Ishii, Yoshiyuki, et al.
Publicado: (2013)

Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
por: Schou, Kenneth B, et al.
Publicado: (2014)

TRAPPC11 and GOSR2 mutations associate with hypoglycosylation of α-dystroglycan and muscular dystrophy
por: Larson, Austin A., et al.
Publicado: (2018)

Novel Compound Heterozygous Mutation in TRAPPC9 Gene: The Relevance of Whole Genome Sequencing
por: Alvarez-Mora, Maria Isabel, et al.
Publicado: (2021)

Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice
por: Rawlins, Lettie E., et al.
Publicado: (2022)

Acetylation increases expression, interaction with TRAPPC4 and surface localization of PD-L1
por: Romeo, Maria Anele, et al.
Publicado: (2023)

Is Circulating Vitamin D Status Associated with the Risk of Venous Thromboembolism? A Meta-Analysis of Observational Studies
por: Hung, Kuo-Chuan, et al.
Publicado: (2023)

A novel deletion variant in TRAPPC2 causes spondyloepiphyseal dysplasia tarda in a five-generation Chinese family
por: Zhang, Cai, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9deiihamu4m7nv9m7acej6je92