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Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3

The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear localization sequence (NLS) comprising residues Pro320 to Asp328, to allow for nuclear translocation. We designed a peptide comprising such...

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Detalles Bibliográficos
Autores principales: Rizzuti, Bruno, Iovanna, Juan L., Neira, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739371/
https://www.ncbi.nlm.nih.gov/pubmed/36499669
http://dx.doi.org/10.3390/ijms232315333