Age-Related Decline in Nrf2/ARE Signaling Is Associated with the Mitochondrial DNA Damage and Cognitive Impairments

In this research, we compared the cognitive parameters of 2-, 7-, and 15-month-old mice, changes in mitochondrial DNA (mtDNA) integrity and expression of genes involved in the nuclear erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) signaling pathway. We showed an age-related dec...

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Detalles Bibliográficos
Autores principales: Gureev, Artem P., Khorolskaya, Victoria G., Sadovnikova, Irina S., Shaforostova, Ekaterina A., Cherednichenko, Vadim R., Burakova, Inna Y., Plotnikov, Egor Y., Popov, Vasily N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739464/
https://www.ncbi.nlm.nih.gov/pubmed/36499517
http://dx.doi.org/10.3390/ijms232315197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739464/
https://www.ncbi.nlm.nih.gov/pubmed/36499517
http://dx.doi.org/10.3390/ijms232315197

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