Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

HIV-1 capsid (CA) performs multiple roles in the viral life cycle and is a promising target for antiviral development. In this work, we describe the design, synthesis, assessment of antiviral activity, and mechanistic investigation of 20 piperazinone phenylalanine derivatives with a terminal indole...

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Detalles Bibliográficos
Autores principales: Xu, Shujing, Sun, Lin, Zalloum, Waleed A., Huang, Tianguang, Zhang, Xujie, Ding, Dang, Shao, Xiaoyu, Jiang, Xiangyi, Zhao, Fabao, Cocklin, Simon, De Clercq, Erik, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739877/
https://www.ncbi.nlm.nih.gov/pubmed/36500508
http://dx.doi.org/10.3390/molecules27238415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739877/
https://www.ncbi.nlm.nih.gov/pubmed/36500508
http://dx.doi.org/10.3390/molecules27238415

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