Cargando…

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

HIV-1 capsid (CA) performs multiple roles in the viral life cycle and is a promising target for antiviral development. In this work, we describe the design, synthesis, assessment of antiviral activity, and mechanistic investigation of 20 piperazinone phenylalanine derivatives with a terminal indole...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Shujing, Sun, Lin, Zalloum, Waleed A., Huang, Tianguang, Zhang, Xujie, Ding, Dang, Shao, Xiaoyu, Jiang, Xiangyi, Zhao, Fabao, Cocklin, Simon, De Clercq, Erik, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739877/ https://www.ncbi.nlm.nih.gov/pubmed/36500508 http://dx.doi.org/10.3390/molecules27238415

Ejemplares similares

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators
por: Zhang, Xujie, et al.
Publicado: (2022)

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2019)

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction
por: Ji, Xiangkai, et al.
Publicado: (2022)

Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation
por: Dick, Alexej, et al.
Publicado: (2022)

Bibliometric analysis and visualization of research trends on HIV-1 capsid inhibitors (2000–2022)
por: Sun, Lin, et al.
Publicado: (2023)

Metabolite Identification of HIV-1 Capsid Modulators PF74 and 11L in Human Liver Microsomes
por: Xu, Shujing, et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents
por: Ghasemi, Saeed, et al.
Publicado: (2020)

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2023)

Recent Advances in HIV-1 Gag Inhibitor Design and Development
por: Dick, Alexej, et al.
Publicado: (2020)

Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
por: Dick, Alexej, et al.
Publicado: (2020)

Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions
por: Dick, Alexej, et al.
Publicado: (2021)

Exploring the Phe-Gly Dipeptide-Derived Piperazinone Scaffold in the Search for Antagonists of the Thrombin Receptor PAR1
por: Valdivielso, Ángel M., et al.
Publicado: (2014)

Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region
por: Zhang, Tao, et al.
Publicado: (2022)

Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778
por: Ji, Xiangkai, et al.
Publicado: (2022)

Structure, Function, and Interactions of the HIV-1 Capsid Protein
por: Rossi, Eric, et al.
Publicado: (2021)

Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus Capsid
por: York, Royce L., et al.
Publicado: (2016)

Binding of a Pocket Factor to Hepatitis B Virus Capsids Changes the Rotamer Conformation of Phenylalanine 97
por: Makbul, Cihan, et al.
Publicado: (2021)

Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles
por: Gao, Shenghua, et al.
Publicado: (2023)

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells
por: Shkundina, Irina S., et al.
Publicado: (2021)

Mechanistic considerations in benzene physiological model development.
por: Medinsky, M A, et al.
Publicado: (1996)

Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study
por: Zhou, Zhenzhen, et al.
Publicado: (2023)

Critical mechanistic features of HIV-1 viral capsid assembly
por: Gupta, Manish, et al.
Publicado: (2023)

Structure–Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication
por: Kortagere, Sandhya, et al.
Publicado: (2014)

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor
por: Meuser, Megan E., et al.
Publicado: (2019)

Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary
por: Xu, Shujing, et al.
Publicado: (2022)

Silver-catalyzed direct selanylation of indoles: synthesis and mechanistic insights
por: Rios, Elise Ane Maluf, et al.
Publicado: (2023)

Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir
por: Bester, Stephanie M., et al.
Publicado: (2022)

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors
por: Gao, Shenghua, et al.
Publicado: (2022)

Phenylalanine meta‐Hydroxylase: A Single Residue Mediates Mechanistic Control of Aromatic Amino Acid Hydroxylation
por: Grüschow, Sabine, et al.
Publicado: (2019)

Anti-Proliferative Effect of Potential LSD1/CoREST Inhibitors Based on Molecular Dynamics Model for Treatment of SH-SY5Y Neuroblastoma Cancer Cell Line
por: Zalloum, Hiba, et al.
Publicado: (2022)

Phenylalanine Binding Is Linked to Dimerization of the Regulatory Domain of Phenylalanine Hydroxylase
por: Zhang, Shengnan, et al.
Publicado: (2014)

Perception, knowledge and attitude towards influenza vaccine during COVID-19 pandemic in Jordanian population
por: Zalloum, Waleed A., et al.
Publicado: (2022)

Activation of Phenylalanine Hydroxylase by Phenylalanine Does Not Require Binding in the Active Site
por: Roberts, Kenneth M., et al.
Publicado: (2014)

Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study
por: Vo, Quan V., et al.
Publicado: (2019)

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity
por: Matreyek, Kenneth A., et al.
Publicado: (2013)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
por: Kumar, Mahesh, et al.
Publicado: (2014)

Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding
por: Stacey, James C. V., et al.
Publicado: (2023)

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
por: Feng, Da, et al.
Publicado: (2022)

Copper Modulates the Catalytic Activity of Protein Kinase CK2
por: Chojnowski, John E., et al.
Publicado: (2022)

(13)C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients
por: Teraishi, T, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qq1si0qdsdpjeh20krcgehjp8v