Current Challenges in Small Molecule Proximity-Inducing Compound Development for Targeted Protein Degradation Using the Ubiquitin Proteasomal System

Bivalent proximity-inducing compounds represent a novel class of small molecule therapeutics with exciting potential and new challenges. The most prominent examples of such compounds are utilized in targeted protein degradation where E3 ligases are hijacked to recruit a substrate protein to the prot...

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Detalles Bibliográficos
Autores principales: Radhakrishnan, Sridhar, Hoff, Oskar, Muellner, Markus K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740444/
https://www.ncbi.nlm.nih.gov/pubmed/36500212
http://dx.doi.org/10.3390/molecules27238119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740444/
https://www.ncbi.nlm.nih.gov/pubmed/36500212
http://dx.doi.org/10.3390/molecules27238119

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