FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages

Formation of foam cells as a result of excess lipid accumulation by macrophages is a pathological hallmark of atherosclerosis. Fingolimod (FTY720) is an immunosuppressive agent used in clinical settings for the treatment of multiple sclerosis and has been reported to inhibit atherosclerotic plaque d...

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Detalles Bibliográficos
Autores principales: Tachibana, Koki, Kusumoto, Kohshi, Ogawa, Mai, Ando, Hidenori, Shimizu, Taro, Ishima, Yu, Ishida, Tatsuhiro, Okuhira, Keiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740778/
https://www.ncbi.nlm.nih.gov/pubmed/36498944
http://dx.doi.org/10.3390/ijms232314617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740778/
https://www.ncbi.nlm.nih.gov/pubmed/36498944
http://dx.doi.org/10.3390/ijms232314617

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