Functional Effects of Epilepsy Associated KCNT1 Mutations Suggest Pathogenesis via Aberrant Inhibitory Neuronal Activity

KCNT1 (K(+) channel subfamily T member 1) is a sodium-activated potassium channel highly expressed in the nervous system which regulates neuronal excitability by contributing to the resting membrane potential and hyperpolarisation following a train of action potentials. Gain of function mutations in...

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Detalles Bibliográficos
Autores principales: Rychkov, Grigori Y., Shaukat, Zeeshan, Lim, Chiao Xin, Hussain, Rashid, Roberts, Ben J., Bonardi, Claudia M., Rubboli, Guido, Meaney, Brandon F., Whitney, Robyn, Møller, Rikke S., Ricos, Michael G., Dibbens, Leanne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740882/
https://www.ncbi.nlm.nih.gov/pubmed/36499459
http://dx.doi.org/10.3390/ijms232315133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740882/
https://www.ncbi.nlm.nih.gov/pubmed/36499459
http://dx.doi.org/10.3390/ijms232315133

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